Angifix(Isosorbide Mononitrate)

Angifix(Isosorbide Mononitrate)

Therapeutic Group: Cardiovascular

Presentation

Each tablet contains Diluted Isosorbide Mononitrate BP equivalent to Isosorbide-5-Mononitrate 20 mg.

Description

Isosorbide-5-mononitrate is an active metabolite of isosorbide dinitrate. It is a vasodilator with effects on both arteries and vein and also coronary vessels. It causes reduction of preload and afterload and redistributes coronary flow to ischemic regions.

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Indications

Treatment and prophylaxis of angina pectoris due to coronary artery disease.

Side Effects

Flushing, throbbing headache, palpitation, dizziness, sweating, skin rash.

Precautions

Severe hypotension, particularly upright posture, may occur with isosorbide mononitrate. This drug should therefore be used with caution in patients who may be volume depleted or who, for whatever reason, are already hypotensive. Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy. This drug should Start with low doses Withdrawn should gradually.

Use in Pregnancy & Lactation

There are no adequate and controlled studies to date with Isosorbide-5-mononitrate in pregnant women, and the drug should be used during pregnancy only when the potential benefit justified possible risks to the fetus.
Execration of Isosorbide-5-mononitrate into human milk is unknown, so precaution should be taken when it is administered to a nursing mother.

Over Dose

Symptoms of over dosage : Most common symptoms are hypotension, throbbing headache, tachycardia, and flushing. Methemoglobinemia may occur with massive doses.

Treatment: Treatment consists of placing patients in recumbent position and administering fluids; alpha-adrenergic vasopressors may be required. Methemoglobinemia should be treated with methyline blue at a dose of 1-2 mg/kg IV slowly.

Commercial Pack

Angifix: Each box containing 5 blister strips of 10 tablets.

FAQ: 

1. What does isosorbide mononitrate do for you?
    Answer :  Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. When used regularly on a long-term basis, this helps prevent angina attacks from occurring.
2. What are the side effects of isosorbide mononitrate?
 Answer :  Side Effects
  • Abnormal heart sound.
  • absence of or decrease in body movement.
  • arm, back, or jaw pain.
  • black, tarry stools.
  • bladder pain.
  • bleeding after defecation.
  • blood in the urine or stools.
  • body aches or pain.

3.What is the best time to take isosorbide mononitrate?

   Answer : You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a “drug-free” period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time.
4.Does isosorbide mononitrate lower BP?
   Answer : Isosorbide mononitrate (ISMN) is effective in the short-term for decreasing systolic blood pressure, pulse pressure, and pulse wave reflection in patients with systolic hypertension.
5.Is isosorbide bad for kidneys?
   Answer : Isosorbide mononitrate (Monoket) is not known to affect the kidneys. People with kidney problems should be able to take the usual dose of isosorbide mononitrate (Monoket).
6.How should isosorbide mononitrate be taken?
   Answer : How to use Isosorbide Mononitrate. Take this medication by mouth as directed by your doctor, usually twice a day. Each day, take the first dose when you wake up, then take the second dose 7 hours later. It is important to take the drug at the same times each day.
7.Can isosorbide mononitrate cause shortness of breath?
    Answer : Signs of an overdose include nausea, vomiting, restlessness, warm flushed skin, blurred vision, headache, fainting, tachycardia (a fast heartbeat), low blood pressure, strong or irregular heartbeat, bluish discoloration of the skin, shortness of breath, rapid shallow breathing and increased pressure within the skull.
8. Does isosorbide make tired?
  Answer : Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. Alcohol may increase certain side effects of isosorbide mononitrate (dizziness, drowsiness, feeling light-headed, or fainting).
9.Does isosorbide cause shortness of breath?
   Answer : A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects.
10.Can you take isosorbide mononitrate at night?
    Answer : You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a “drug-free” period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time.
11.Should I take food with isosorbide mononitrate?
    Answer : Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Take your medicine at regular intervals.
12.How long does it take isosorbide to work?
  Answer :  After oral administration, isosorbide mononitrate EL has a quick onset of action (30 minutes) and effects are evident for up to 17 hours.
13.Does isosorbide mononitrate affect your kidneys?
    Answer : Long-term administration of isosorbide-5-mononitrate does not impair renal function in cirrhotic patients. Hepatology.
14.Can isosorbide be stopped suddenly?
   Answer : Use isosorbide mononitrate regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely. You should not stop using isosorbide mononitrate suddenly or you could have a severe attack of angina. Keep this medicine on hand at all times.
15.How long do headaches last with isosorbide?
   Answer : One of the most common side effects of isosorbide dinitrate is headaches. Do not stop taking this drug if a headache occurs; a headache is a sign that isosorbide dinitrate is working. Headaches usually develop after first taking isosorbide dinitrate and subside after a couple of weeks.

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