Cefixime Trihydrate USP : Emixef(Cefixime)

Cefixime Trihydrate USP : Emixef(Cefixime)

Therapeutic Group: Cephalosporins


Emixef 200 Capsule: Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 200 mg.

Emixef 400 Capsule: Each capsule contains Cefixime Trihydrate USP equivalent to Cefixime 400 mg.

Emixef Powder for Suspension: After reconstitution according to direction, each 5 ml suspension contains Cefixime Trihydrate USP equivalent to Cefixime 100 mg.

Emixef DS Powder for Suspension: After reconstitution according to direction, each 5 ml suspension contains Cefixime Trihydrate USP equivalent to Cefixime 200 mg.

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Cefixime is a semi-synthetic, broad spectrum cephalosporin antibiotic of third generation for oral administration. It is a bactericidal antibiotic, kills bacteria by interfering in the synthesis of the bacterial cell wall. Cefixime is highly stable in the presence of beta-lactamase enzymes. Cefixime has marked in -vitro bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms including beta lactamase producers.

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Clinical efficacy of Cefixime has been demonstrated in infections caused by commonly occurring pathogens including Gram-positive organism Streptococcus pneumoniae, Streptococcus pyogenes, Gram-negative organism Escherichia coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative), Salmonella typhi and Enterobacter species.


Emixef is indicated in the following infectious diseases –

Respiratory Tract Infections:



Pharyngitis and Tonsillitis

Acute Bronchitis and Acute Exacerbations of Chronic

Bronchitis (AECB)

Otitis Media

Typhoid Fever

Urinary Tract Infections

Uncomplicated gonorrhea (cervical/urethral)

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Dosage & Administration

The usual treatment of Emixef is 7 days. This may be continued for up to 14 days according to the severity of infection.

Emixef Capsule

Adult and child over 12 years: 200 or 400 mg daily as a single dose or in two divided doses.

Emixef Suspension

Child over 6 months: 8 mg/kg daily as a single dose or in 2 divided doses

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Side Effects

Cefixime is generally well tolerated. The majority of adverse reactions observed in clinical trials are mild and self limiting in nature.
Gastro-intestinal disturbance: Diarrhea (if severe diarrhea occurs, Cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence have been reported. CNS disturbances: Headache, dizziness.

Others: Hypersensitivity reactions which usually subsided upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase.

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Cefixime should be prescribed with caution in individuals with a history of gastrointestinal diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance < 20 ml/min)


Use in Pregnancy & Lactation

Pregnancy: Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Lactation: It is not known whether Cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with this drug.

Use in Elderly

No special precautions are necessary. No dosage adjustment is required for elderly

Drug Interaction

Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when Cefixime is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.

Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly.

Over Dose

Gastric lavage may be indicated; otherwise, no specific antidote exists. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Adverse reactions in small numbers of healthy adult volunteers receiving single doses up to 2 g of Cefixime did not differ from the profile seen in patients treated at the recommended doses.

Commercial Pack

Emixef 200 Capsule: Box containing 2 Alu-Alu blister strips of 6 capsules.
Emixef 400 Capsule: Box containing 2 Alu-Alu blister strip of 4 capsules.

Emixef Suspension: Bottle containing powder for the preparation of 50 ml, 40 ml or 30 ml suspension.

Emixef DS Suspension: Bottle containing powder for the preparation of 50 ml suspension.


Direction for Reconstitution of Suspension

• To prepare 50 ml suspension, 25 ml boiled and cooled water is required.

• To prepare 40 ml suspension, 20 ml boiled and cooled water is required.

• To prepare 30 ml suspension, 15 ml boiled and cooled water is required.

• To prepare 50 ml DS suspension, 25 ml boiled and cooled water is required.

Tap the bottle several times to loosen powder contents prior to reconstitution. Add approximately half of the total amount of water and shake well. Add remainder of water, and then shake again.
Note: Shake the suspension well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 14 days.

  1. What is the use of cefixime trihydrate?

Answer : Cefixime is used to treat certain infections caused by bacteria such as bronchitis (infection of the airway tubes leading to the lungs); gonorrhea (a sexually transmitted disease); and infections of the ears, throat, tonsils, and urinary tract. Cefixime is in a class of medications called cephalosporin antibiotics.


  1. Is cefixime a strong antibiotic?

Answer : Cefixime is generally a strong antibiotic as it is used actively against a broad category of bacteria.


  1. What is trihydrate tablets used for?

Answer :  It is a penicillin-type antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu).

  1. Can cefixime be used for fever?

Answer :  All patients responded rapidly to treatment and were cured clinically and bacteriologically. Fever subsided within a mean of 5.3 days (range 3-8 days). Only two of the 50 patients treated relapsed during the 8 week follow-up period. No serious adverse reactions attributable to the drug were observed.

  1. Is cefixime safe for kidney patients?

Answer :  As with other cephalosporins, cefixime may cause acute renal failure including tubulointerstitial nephritis as an underlying pathological condition. When acute renal failure occurs, cefixime should be discontinued and appropriate therapy and/or measures should be taken.

  1. Is cefixime safe?

Answer : Call your doctor right away if you or your child has a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. Cefixime may cause diarrhea, and in some cases it can be severe.

  1. Can I take cefixime for 3 days?

Answer :  The respective microbiological cure rates (free of bacteriuria) for the two groups of women were 83 and 86% after 7 days and 77 and 80% after 28 days. A 3-day cefixime regimen seems to be as efficient as a 3-day ofloxacin regimen in the treatment of uncomplicated cystitis in women.

  1. What is the side effects of cefixime?

Answer :  SIDE EFFECTS: Stomach upset/pain, diarrhea, nausea, gas, headache, or dizziness may occur.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • jaundice (yellowing of the skin or eyes);
  • pale or yellowed skin, dark colored urine, confusion or weakness;
  • a seizure (convulsions);


  1. Can we use cefixime for urinary tract infection?

Answer : Cefixime, a new oral cephalosporin, is more active against enterobacteriaceae than the conventional oral cephalosporins. About 20% of the drug is excreted by the kidneys as active drug. Therefore, the treatment of urinary tract infection (UTI) by cefixime may be a good alternative.

  1. What is trihydrate formula?

Answer :  Molecular Formula. C16H25N3O8S. Synonyms. Amoxicillin trihydrate.


  1. What is a trihydrate?

Answer :  trihydrate. / (traɪˈhaɪdreɪt) / noun. chem a substance that contains three molecules of water.


  1. Which antibiotic is best for urinary infection?

Answer :  Trimethoprim/sulfamethoxazole, nitrofurantoin, and fosfomycin are the most preferred antibiotics for treating a UTI.


  1. Which is better azithromycin or cefixime?

Answer :  Clinical cure rate was 87% in azithromycin group and 93% in cefixime group. No serious adverse effect was noted related to azithromycin and cefixime therapy except nausea, vomiting, diarrhoea and jaundice. It was found that azithromycin is almost as effective as cefixime in the treatment of typhoid fever.


  1. Which is best medicine for fever?

Answer :  In the case of a high fever, or a low fever that’s causing discomfort, your doctor may recommend an over-the-counter medication, such as acetaminophen (Tylenol, others) or ibuprofen (Advil, Motrin IB, others). Use these medications according to the label instructions or as recommended by your doctor.


  1. Who should not take cefixime?

Answer :  You should not take cefixime if you are allergic to cefixime, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others. Tell your doctor if you are allergic to penicillins.

  1. How many times a day should I take cefixime?

Answer :  For infections: Adults and children older than 12 years of age and weighing more than 50 kilograms (kg)—400 milligrams (mg) once a day or 200 mg every 12 hours.


  1. Can cefixime cause death?

Answer :  Anaphylactic/anaphylactoid reactions (including shock and fatalities) have been reported with the use of cefixime. Before therapy with SUPRAX is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs.

  1. Which antibiotic is safe for kidney?

Answer :  Penicillins are generally well tolerated in patients with kidney disease. Hypersensitivity reactions are commonly reported, and an association between penicillins and interstitial nephritis exists, but patients with kidney disease are not considered to be at higher risk (10).

  1. How long cefixime can be taken?

Answer :  Cefixime is usually taken once or twice a day for 7 to 14 days. It can be taken either with or without food.

  1. What is Ceftas 200 used for?

Answer : Ceftas CV 200 Tablet 10’s belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, ear, throat, lungs, and uncomplicated gonorrhoea. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body.

  1. What is bacterial infection?

Answer :  A bacterial infection is a proliferation of a harmful strain of bacteria on or inside the body. Bacteria can infect any area of the body. Pneumonia, meningitis, and food poisoning are just a few illnesses that may be caused by harmful bacteria.


  1. Can I take cefixime 400mg twice a day?

Answer :  How to use cefixime oral. Take this medication by mouth with or without food as directed by your doctor, usually once a day. In children, this medication may also be taken twice a day (every 12 hours). If you are taking the chewable tablets, chew thoroughly and then swallow.

  1. Can I take cefixime for 5 days?

Answer :  In summary, 5-day cefixime 400 mg in AECB is clinically and bacteriologically equivalent to the standard 10-day treatment. This indication may also have better safety characteristics.

  1. Is cefixime safe in diabetes?

Answer : You may need to stop nursing while you are taking cefixime.

Talk to your doctor before using this form of cefixime if you have diabetes.

  1. How do you eat dispersible tablets?

Answer :  HOW TO USE: Remove the tablet from its foil pack and place the tablet immediately on the tongue. It will dissolve quickly. You may take this medication with or without water. Take this medication by mouth once a day or as directed by your doctor.

  1. Which antibiotic is safe for heart patients?

Answer :  Azithromycin is the most extensively studied and tested antibiotic to date for application to coronary heart disease (CHD). Azithromycin is readily taken up into atherosclerotic plaque. We and others have found it to be effective in animal models.

  1. What antibiotic is cefixime?

Answer :  Cefuzime 500 Tablet is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive

  1. Which is better ciprofloxacin or Cefixime?

Answer :  Bacteria cure was obtained in 96% of the patients in the cefixime group and 83% in the ciprofloxacin group. Conclusion: Cefixime was found to be superior to ciprofloxacin in terms of efficacy in the treatment of community-acquired pneumonia in adults in Nigeria.

  1. How long does Cefixime take to work for UTI?

Answer :  Was switched to Cefixime for this and it worked like a charm in less than 24 hours.” Suprax (cefixime) for Bladder Infection: “While this medication cured my UTI it left me with debilitating c-diff.

  1. How long should I take Cefixime for UTI?

Answer :  Some people will need to take these medicines for up to 7 to 10 days. For a complicated infection, you might need to take antibiotics for 14 days or more.

  1. Is sodium acetate trihydrate safe?

Answer :  Inhalation: It may cause irritation to the respiratory tract. Symptoms may include coughing, sore throat and labored breathing. Ingestion: In large doses may produce abdominal pain, nausea, and vomiting. Skin Contact: It may cause irritation with redness and pain.

  1. Is amoxicillin a trihydrate?

Answer : Amoxil contains a penicillin called amoxicillin (as trihydrate) as the active ingredient. Amoxil belongs to a group of medicines called penicillins. Amoxicilllin works by killing the bacteria that cause these infections.

  1. What is the percent of water in sodium acetate trihydrate?

Answer :  Properties

Property Value
Purity Percentage 99.5
Purity Details >=99.5%
Solubility in Water 1.100 g/l (20 °C)
Upper Explosion Limit Not applicable
  1. What is the use of amoxycillin trihydrate tablets?

Answer :  Amoxicillin is used to treat a wide variety of bacterial infections. This medication is a penicillin-type antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.

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