Clomipramine Hydrochloride | Uses, Side Effects Etc.

Clopramin(Clomipramine Hydrochloride)

Therapeutic Group: Tricyclic Antidepressant

Presentation

Clopramin Tablet: Each tablet contains Clomipramine Hydrochloride USP 25 mg.

Description

Clomipramine Hydrochloride is an original tricyclic antidepressant, a member of the dibenzazepine group of compounds. It is presumed to influence obsessive and compulsive behaviors through it’s effects on serotonergic neuronal transmission. The actual neurochemical mechanism is unknown but it has the capacity to inhibit the reuptake of serotonin (5-HT) which is thought to be important ( like obsessions, compulsion) thus hampers social acquaintance.

Indications

Obsessive Compulsive Disorder (OCD), Major Depressive Disorder (MDD), Depression

Dosage & Administration

Initial dose is 25 mg at bed time about a week, gradual increase of dose should not be exceeded more than 150 mg per day in adult and 75 mg per day in elderly patient. Dose can be given as divided form to reduce gastrointestinal disturbances.

Side Effects

The most frequent side effects are gastrointestinal disturbances, Headache, dizziness, nausea, constipation, dry mouth, increased sweating, shaking hands, tremor, difficulty in passing urine, problems with their eyes, feeling tired or sleepy, sexual disturbance, restlessness.

Precautions

Talk to your doctor or pharmacist before taking Clomipramine if you:
– have ever had suicidal thoughts
– suffer from epilepsy (fits)
– have had a head injury or have suffered brain damage
– are going to have electric shock therapy (ECT)
– have other problems with your heart
– have been told you have a low level of potassium in your blood (hypokalaemia).
The doctor will need to treat this before you start taking clomipramine
– have kidney disease
– suffer from schizophrenia or other mental health conditions
– have a blood disorder
– have an overactive thyroid gland
– have had severe constipation for a long time
– have a tumour (cancer) of the adrenal gland (such as phaeochromocytoma or neuroblastoma)
– liver disease
– have low blood pressure
– wear contact lenses

Use in Pregnancy & Lactation

Clomipramine Hydrochloride No adequate well-controlled studies of safety for pregnancy. Limited data suggest that clomipramine is likely to be excreted in human breast milk. Although it has known risk of damage to fetus.

Read More :  The Ultimate Guide : Adalimumab used, side effects and more

Over Dose

Clomipramine Hydrochloride has been reported that adults can experience dryness of mouth, dilated pupils, coma, convulsions. Tachycardia/ cardiac arrhythmia, respiratory depression and alteration in blood pressure are noted.

Storage

Clomipramine Hydrochloride Do not store above 30 ° C. Keep away from light and out of the reach of children

Commercial Pack

Clomipramine Hydrochloride (Clopramin Tablet): Each box contains 3 blister strips of 10 Tablets.

FAQ:

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1.What is clomipramine hydrochloride used for?

Answer : Clomipramine is used to treat people with obsessive-compulsive disorder (a condition that causes repeated unwanted thoughts and the need to perform certain behaviors over and over). Clomipramine is in a group of medications called tricyclic antidepressants.

 

2.Is clomipramine good for anxiety?

Answer : Clomipramine is used off-label to treat patients with depression, anxiety, treatment-resistant depression, cataplexy syndrome, insomnia, neuropathic pain, chronic pain, body dysmorphic disorder, panic disorder, premature ejaculation, pediatric nocturnal enuresis, and trichotillomania.

 

3.Is clomipramine a good antidepressant?

Answer : Clomipramine has an average rating of 7.2 out of 10 from a total of 33 ratings for the treatment of Depression. 70% of reviewers reported a positive effect, while 24% reported a negative effect.

 

4.How does clomipramine make you feel?

Answer : Clomipramine can make you feel sleepy so your doctor may advise you to take a small dose when you first start taking it, and then to increase your dose gradually as your body gets used to it. It is usual to take clomipramine once a day at bedtime, although it can also be taken in smaller doses two or three times a day.

 

5.Does clomipramine help you sleep?

Answer : Clomipramine produced rapid changes in sleep with reduced sleep continuity and almost complete suppression of REM sleep as well as a redistribution of slow wave sleep. Delta waves during sleep were also found to be shifted to the earlier part of the night and increased in intensity.

 

6.Is clomipramine a sedative?

Answer : In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood.

7.Is clomipramine a good antidepressant?

Answer : Clomipramine has an average rating of 7.2 out of 10 from a total of 33 ratings for the treatment of Depression. 70% of reviewers reported a positive effect, while 24% reported a negative effect.

8.How does clomipramine make you feel?

Answer : Clomipramine can make you feel sleepy so your doctor may advise you to take a small dose when you first start taking it, and then to increase your dose gradually as your body gets used to it. It is usual to take clomipramine once a day at bedtime, although it can also be taken in smaller doses two or three times a day.

9.Does clomipramine make you happy?

Answer :Clomipramine has a sedative effect that can make it useful for treating depression in people who also suffer from anxiety, or who are having problems sleeping. Clomipramine won’t change your personality or make you feel instantly happy and relaxed.

10.Does clomipramine help you sleep?

Answer : Clomipramine produced rapid changes in sleep with reduced sleep continuity and almost complete suppression of REM sleep as well as a redistribution of slow wave sleep. Delta waves during sleep were also found to be shifted to the earlier part of the night and increased in intensity.

11.What are some of the side effects of Prozac?

Answer : Side effects of Prozac include:

  • nausea,
  • upset stomach,
  • constipation,
  • headaches,
  • anxiety,
  • sleep problems (insomnia),
  • drowsiness,
  • dizziness,
  • Does clomipramine make you hungry?
  • Clomipramine was significantly associated with increased hunger, appetite and energy intake. It tended, though, to be associated with a reduced rate of weight gain, possibly because activity was increased.

 

 

12.Is clomipramine a sedating?

Answer : Clomipramine is an exception, although as a tertiary amine, it is not as sedating as amitriptyline, imipramine, or doxepin and may be activating in some individuals.

13.Can clomipramine cause weight gain?

Answer : Commonly reported side effects of clomipramine include: constipation, dizziness, drowsiness, dyspepsia, ejaculatory disorder, fatigue, headache, insomnia, myoclonus, nausea, nervousness, paresthesia, tremor, urination disorder, visual disturbance, weight gain, anorexia, diaphoresis, and xerostomia.

14.How does clomipramine work on the brain?

Answer : Clomipramine works by affecting the activity of brain chemicals (neurotransmitters) called serotonin and norepinephrine. Clomipramine enhances the action of these chemicals in parts of the brain that control concentration, motivation and mood.

15.Can you drink alcohol on clomipramine?

Answer : Do not drink alcohol while you are taking clomipramine. Mixing alcohol with clomipramine may increase the risk of other side effects such as drowsiness, confusion, blurred vision.

16.Does clomipramine increase serotonin?

Answer : Clomipramine increases the levels of serotonin in the brain. Co-administration with other medications that also increase serotonin levels increases the risk of serotonin syndrome.

17.What time of day should you take clomipramine?

Answer : It is best to take this medicine with food. Take this medicine at bedtime to lessen drowsiness during the day.

18.What antidepressant is good for insomnia?

Answer :  The sedating antidepressants most commonly used to help with sleep include Trazodone (Desyrel), Amitriptyline (Elavil), and Doxepin (Sinequan). It should be noted that when these medications are used for sleeping and pain relieving properties, it is in much lower doses than when used in the treatment of depression.

19.Why was Prozac taken off the market?

Answer :  Prozac recall
The use of Prozac is known to cause serious side effects including suicidal ideation (thinking of suicide) and suicide action along with birth defects and serotonin syndrome. Even so, the FDA nor Eli Lilly and Company have yet to recall the product from the medical marketplace.

20.Is Prozac a happy pill?

Answer : The original “happy pill” was fluoxetine, more commonly known as Prozac. This medication, approved for use in 1987, was the first drug of its kind to be prescribed and marketed on a large scale. The use of this medication is very common, especially for the treatment of depression, but it is not without its risks.

21.Is Anafranil the same as clomipramine?

Answer : Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). It is used for the treatment of obsessive–compulsive disorder, panic disorder, major depressive disorder, and chronic pain.

22.Can I have a glass of wine while taking diclofenac?

Answer : Yes, you can drink alcohol while taking diclofenac. But drinking too much alcohol may irritate your stomach.

23.What is best medication for OCD and Anxiety?

Answer : Antidepressants approved by the U.S. Food and Drug Administration (FDA) to treat OCD include:

  • Clomipramine Hydrochloride (Anafranil) for adults and children 10 years and older.
  • Fluoxetine (Prozac) for adults and children 7 years and older.
  • Fluvoxamine for adults and children 8 years and older.
  • Paroxetine (Paxil, Pexeva) for adults only.

24.What is dapoxetine used for?

Answer : About dapoxetine
Dapoxetine is a selective serotonin reuptake inhibitor medicine which has specially been developed for the treatment of premature ejaculation. It increases the time it takes to ejaculate and can improve the control over the ejaculation.

25.What can you not take with clomipramine?

Answer : Drugs that should not be used with clomipramine
When used with Clomipramine Hydrochloride, these drugs can cause dangerous effects in the body. Examples of these drugs include: Monoamine oxidase inhibitors such as selegiline, and drugs such as linezolid, methylene blue, fentanyl, tramadol, lithium, buspirone, and St. John’s wort.

 

26.What happens if a human takes clomicalm?

Answer : The following adverse reactions have been reported associated with administration of Clomipramine Hydrochloride: lethargy/depression, vomiting, diarrhea, elevation in liver enzymes, convulsion(s), increased heart rate, decreased heart rate, increased thirst and confusion.

27.What is the best medication for anxiety and sleep?

Answer : Benzodiazepines hasten sleep onset, decrease nocturnal awakenings, increase total sleeping time, and reduce pathological anxiety, agitation and tension. 3.8. According to the WHO EML, essential medicine for anxiety and sleep disorders is diazepam.

28.What is the best antidepressant for sleep anxiety?

Answer : Sedating antidepressants that can help you sleep include: Doxepin (Silenor) Mirtazapine (Remeron) Trazodone (Desyrel)

SSRIs.

  • Citalopram (Celexa)
  • Fluoxetine (Prozac)
  • Paroxetine (Paxil)
  • Sertraline (Zoloft)

Clomipramine Hydrochloride

29.Is Prozac similar to Xanax?

Answer : Xanax and Prozac belong to different drug classes. Xanax is a benzodiazepine and Prozac is a selective serotonin reuptake inhibitor (SSRI) antidepressant.

30.Does Prozac permanently change brain?

Answer : Selective serotonin reuptake inhibitors (SSRI) such as Prozac are regularly used to treat severe anxiety and depression. They work by immediately increasing the amount of serotonin in the brain and by causing long term changes in brain function.

31.What is the #1 antidepressant?

Answer : Zoloft is the most commonly prescribed antidepressant; nearly 17% of those surveyed in the 2017 antidepressant use study reported that they had taken this medication.

32.What are the side effects of clomipramine?

Answer : Clomipramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry mouth.
  • decreased sexual ability.
  • How safe is clomipramine?
  • Clomipramine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

 

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