World No 1 Best selling : Pedilid(Roxithromycin)

Pedilid(Roxithromycin)

Therapeutic Group: Anti Bacterial

Presentation

Pedilid 150: Each film-coated tablet contains Roxithromycin BP 150 mg.

Pedilid 300: Each film-coated tablet contains Roxithromycin BP 300 mg.

Pedilid powder for suspension: When reconstituted each 5 ml suspension contains Roxithromycin BP 50 mg.

Description

Roxithromycin, is a macrolide with antibacterial properties similar to erythromycin. It is active against Gram-positive bacteria like staphylococci, streptococci, listeria, corynebacteria; Gram-negative bacteria such as gonococci, Haemophilus influenzae, Haemophilus ducreyi, Legionella, campylobacter, and atypical pathogens like Mycoplasma and Chlamydia. Roxithromycin has been found useful in the treatment of upper and lower respiratory tract infection, otorhinolaryngological, skin, dental and genital infections. It is well tolerated by adults and children.

Indications

Roxithromycin is indicated in the treatment of infections caused by susceptible microorganisms;

Respiratory infections like pneumonia, acute and chronic bronchitis, and bronchopneumonia

ENT infections like tonsillitis, pharyngitis, sinusitis and otitis media.

Skin infections like folliculitis, furuncles, cellulitis, carbuncles, pyoderma, impetigo and infected dermatitis.

Genital infections like urethritis, prostatitis, cervicitis and salpingitis especially if produced by Chlamydia trachomatis.

Dosage & Administration

Adult dose: The usual dose for adults is one 300 mg tablet once daily or one 150 mg tablet twice a day for at least two days after resolution of symptoms, a normal course of therapy is between 5 and 10 days. Roxithromycin is best administered on empty stomach. In severe hepatic impairment the dose is 150 mg once daily.
Paediatric dose: The dose for children is 2.5 to 5 mg/kg body weight twice a day. The following general guidelines can be followed
6 to 11 Kg: 25 mg Roxithromycin 12 hourly.
12 to 23 Kg: 50 mg Roxithromycin 12 hourly.
24 to 40 Kg: 100 mg Roxithromycin 12 hourly.
A normal course of therapy is between 5 and 10 days.

Side Effects

Roxithromycin is well tolerated by patients of all age groups. Less than 4% of treated patients complain of side effects mainly nausea, abdominal pain, diarrhoea and hypersensitivity rash. Other side effects reported include vomiting, dizziness, headache, pruritus, dyspepsia, flatulence, tinnitus, vertigo and constipation. These are in general minor and do not necessitate withdrawal of therapy.

Precautions

Roxithromycin should not be used in patients with a history of hypersensitivity to the drug. In patients with hepatic diseases the dose of Roxithromycin should not exceed 150 mg twice a day.

Use in Pregnancy & Lactation

The safety of Roxithromycin in pregnancy has not been established. It appears in breast milk in small amounts and dose not produce adverse effects in the breast fed infant.

Drug Interaction

Roxithromycin does not have any affinity for cytochrome P- 450 binding sites and thus is unlikely to produce drug interaction mediated by this enzymatic system. Roxithromycin shows mild interaction with theophylline though this has not been found to produce clinically relevant effects. Alteration in the pharmacokinetics of carbamazepine or warfarin has not been found. Antacids, H2- receptor antagonists and food has no effect on the absorption of Roxithromycin.

Commercial Pack

Pedilid 150: Each box containing 5 blister strips of 10 tablets.
Pedilid 300: Each box containing 3 blister strips of 10 tablets.
Pedilid powder for suspension: Bottle containing Roxithromycin powder to produce 50 ml suspension.

Others

Roxithromycin is well absorbed on oral administration and achieves plasma and tissue concentrations well above the minimum inhibitory concentrations for susceptible microorganisms. Effective bactericidal concentrations are found in tonsils, pharynx, adenoids, paranasal sinuses, bronchi, sputum, skin, gums, prostate and gynaecologic tissue. Mean peak plasma concentrations of about 7 mcg/ml are found 1.5 hours after an oral 300 mg or 150 mg dose of Roxithromycin. Roxithromycin has a mean plasma half-life of 9 to 16 hours and once or twice daily dosing is sufficient to maintain adequate bactericidal activity in plasma and tissues. It is metabolized by the liver to inactive metabolites. Excretion occurs mainly through feces and also through respiratory tract and urine. The plasma protein binding varies from 30 to 50 percent. Roxithromycin pharmacokinetics is similar in infants, children, adults, and elderly. Accumulation does not occur in patients with compromised renal function and dosage adjustment is not necessary. In patients with severe hepatic dysfunction the elimination half-life is prolonged and a dose of 150 mg twice a day should not be exceeded.

 

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 FAQ: 
1.When should I take roxithromycin?
Answer : ARROW – ROXITHROMYCIN should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). ARROW – ROXITHROMYCIN works best if you take it on an empty stomach. Food in the stomach can reduce the absorption of ARROW – ROXITHROMYCIN.
2.Is roxithromycin the same as amoxicillin?
Answer : Amoxicillin and roxithromycin are equally effective in the treatment of patients presenting with lower respiratory tract infections and needing antibiotic treatment. Most patients remain symptomatic after 10 days of treatment with either drug.
3.Which is better azithromycin or roxithromycin?
Answer : Azithromycin appears to be as effective as roxithromycin for the treatment of atypical pneumonia. The 3-day azithromycin regimen may offer an additional advantage over 10-day roxithromycin by virtue of its more convenient administration.
4.Is roxithromycin stronger than amoxicillin?
Answer : The results indicate that both drugs are equally effective in the treatment of respiratory tract infection, but that roxithromycin is better tolerated.
5.What is roxithromycin used to treat?
Answer : Roxithromycin is an antibiotic that is used to treat infections such as infections of the chest, tonsils, skin or genitals. It works by killing or stopping the growth of bacteria (bugs). Like all antibiotics, roxithromycin is not effective against infections caused by viruses.
6.Can roxithromycin treat pneumonia?
Answer :  An open multicentre study of the efficacy and side effects of roxithromycin, a new macrolide antibiotic, in the treatment of community acquired pneumonia was undertaken. The diagnosis was verified by transtracheal aspiration.
7.Does roxithromycin treat bronchitis?
Answer :  Lower respiratory tract infection: acute bronchitis and acute exacerbations of chronic bronchitis; community acquired pneumonia. Skin and skin structure infections.
8.What are the side effects of roxithromycin tablets?
Answer :  Nausea, vomiting, stomach pain, diarrhoea, flatulence, loss of appetite. red and/or itchy skin, skin rash. headache, tiredness, dizziness, pins and needles, ringing in the ears. hallucinations.
9. How effective is Roxithromycin?
Answer : Influence of roxithromycin regimen. The overall response rate in all studies was 76% (163 out of 214 cases; 95% CI: 71, 82) for the 150 mg twice daily regimen and 87% (34 out of 39 cases) for the 300 mg once daily regimen; a non significant difference was found.
Clinical response of comparator antibiotics.
10.Can azithromycin and roxithromycin be taken together?
Answer :  The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Roxithromycin. The metabolism of Baricitinib can be decreased when combined with Roxithromycin.
11.Is roxithromycin good for throat infection?
Answer : Roxithromycin is a macrolide antibiotic that treats bacterial infections of the throat, airways, tonsils, lungs, skin, and urinary tract, which includes kidneys, bladder, ureters, and urethra. This medication kills or slows the bacteria that cause the infection.
12.Why is roxithromycin not available in the US?
Answer : Roxithromycin is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. Because of the low levels of roxithromycin in breastmilk, it would not be expected to cause adverse effects in breastfed infants.
13.Can you drink alcohol with Roxithromycin?
Answer :  While some people say alcohol can reduce the effectiveness of antibiotics, there’s little evidence to support this. Even if there was, alcohol breaks down in the body relatively quickly. So drinking a glass or two at dinner is unlikely to significantly interfere with an antibiotic taken daily for five to seven days.
14. Does roxithromycin treat sinus infection?
Answer : Roxithromycin thus appears to be an effective and well-tolerated drug for the treatment of acute and recurrent sinusitis.
15.What is the difference between erythromycin and roxithromycin?
Answer : More patients reporting adverse events were on erythromycin than on roxithromycin (51.3% vs 17.5%; p = 0.003). The results suggest that roxithromycin is as effective as erythromycin stearate in the treatment of lower respiratory tract infections and causes fewer adverse effects.
16.Can roxithromycin treat acne?
Answer : Roxithromycin has a therapeutic effect on inflammatory acne and leads to improvement of quality of life in the patients.
17.Is roxithromycin good for acne?
Answer :  3,4 In March 1999, the use of roxithromycin was approved in Japan for the additional indication of acne associated with inflammation, and it is recognized as a useful agent for the treatment of acne.
18.How long does it take for antibiotics to work?
Answer : Antibiotics begin to work right after you start taking them. However, you might not feel better for two to three days. How quickly you get better after antibiotic treatment varies. It also depends on the type of infection you’re treating.
19. Can you take pain relief with antibiotics?
Answer : Yes! It is safe to use paracetamol at the same time as taking most antibiotics. Taking antibiotics at the same time as paracetamol shouldn’t cause any problems.
20.What is the difference between roxithromycin and doxycycline?
Answer : Though patient numbers are too small for statistically significant differences to be detected, we conclude that the results to date suggest that roxithromycin and doxycycline are equivalent in terms of efficacy, but that roxithromycin is better tolerated.
21.Is roxithromycin same as rulide?
Answer : Each Rulide tablet contains either 150mg or 300mg of the active ingredient roxithromycin.
22.What is the strongest antibiotic for upper respiratory infection?
Answer : Amoxicillin is the preferred treatment in patients with acute bacterial rhinosinusitis. Short-course antibiotic therapy (median of five days’ duration) is as effective as longer-course treatment (median of 10 days’ duration) in patients with acute, uncomplicated bacterial rhinosinusitis.
23.What is rosuvastatin 20mg?
Answer :  Rosuvastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver.
24.What are the side effects of Roxithromycin?
Answer :  Gastrointestinal : Nausea, vomiting, abdominal pain, diarrhea, loss of appetite, constipation, indigestion and flatulence.
25.Is amikacin a strong antibiotic?
Answer : Amikacin is an antibiotic that fights bacteria. Amikacin is used to treat severe or serious bacterial infections. Amikacin may also be used for purposes not listed in this medication guide.
26.What is the use of Roxid 150?
27.What is the drug Roxy?
Answer : Roxicodone (oxycodone) is an opioid analgesic prescribed to treat moderate to severe pain. Roxicodone is available as a generic drug.
28. How strong is roxithromycin?
Answer : Each tablet contains 150 mg or 300 mg of roxithromycin. For the full list of excipients, see section 6.1. White, round, coated tablets.
29.Can roxithromycin treat urine infection?
Answer : Roxithromycin works as an antibacterial agent by binding to the bacterial ribosome and disrupting protein synthesis. It’s used for the treatment of infections related to the respiratory tract, urinary tract, and soft tissues.

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